Shaquille O'Neal is a guest-star character who is a fictional version of the former professional basketball player with the same name who during his nineteen-year-long career is known for playing center in six different basketball teams in the NBA, as well as being known as one of the greatest basketball players of all time.
Shaquille O'Neal appeared in the episode "Back on Shaq", where he had a temporary bad luck streak and kept missing basket shots, until when Johnny Bravo showed up and his presence seemed to have given Shaq good luck and made his shots unmissable. Which made Shaq appoint Johnny as his partner and gained an unbeatable advantage. They both end up challenging Seth Green, who like Shaq is using a Hanna-Barbera character to give him a good luck streak, to which that character is Huckleberry Hound. The game is in Shaq's favor up until Johnny needs to use the bathroom, seemingly giving Shaq a disadvantage, but is able to make the shot and decides he no longer needs Johnny.